Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin

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Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin

Oxidized cell-free hemoglobin (Hb), including covalently cross-linked Hb multimers, is present in advanced atherosclerotic lesions. Oxidation of Hb produces methemoglobin (Fe(3+)) and ferryl hemoglobin (Fe(4+) = O(2-)). Ferryl iron is unstable and can return to the Fe(3+) state by reacting with specific amino acids of the globin chains. In these reactions globin radicals are produced followed b...

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ژورنال

عنوان ژورنال: Oxidative Medicine and Cellular Longevity

سال: 2013

ISSN: 1942-0900,1942-0994

DOI: 10.1155/2013/676425